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Indian Journal of Contemporary Dentistry
Year : 2016, Volume : 4, Issue : 1
First page : ( 96) Last page : ( 100)
Print ISSN : 2320-5806. Online ISSN : 2320-5962.
Article DOI : 10.5958/2320-5962.2016.00022.X

Fibrous Dysplasia-A Hallmark Fibro-Osseous Lesion of Bone: An Overview

Khare Ankita1,*, Prasad Krishna Deo2, Sublok Karan3, Tak Jalaj4, Gupta Vineet4, Bali Ruchita5, Jan Iram1, Mittal Sachin6

1Post Graduate Student, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh

2Prof. & Head, Dept. of Oral Pathology & Microbiology, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh

3Post Graduate Student, Dept. of Oral & maxillofacial Surgery, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh

4Reader, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh

5Senior Lecturer, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh

6Reader, Dept. of Oral Medicine & Radiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh

*Corresponding author: Dr. Ankita Khare Post Graduate Student, Dept. of Oral and Maxillofacial Pathology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh. Email: ankita.khare14@gmail.com

Online published on 7 March, 2016.

Abstract

Fibrous dysplasia is a common benign skeletal lesion that may involve one bone (monostotic) or multiple bones (polyostotic) and occurs throughout the skeleton with a predilection for the long bones, ribs, and craniofacial bones. The etiology of Fibrous dysplasia has been linked to the posygotic mutation in the GNAS 1 (guanine nucleotide-binding protein, alpha stimulating activity polypeptide 1) gene (20ql3.2–13.3) resulting in up-regulation of cAMP. It may be isolated to a single skeletal site or multiple sites and sometimes is associated with extraskeletal manifestations in the skin and/or endocrine organs (McCune-Albright syndrome).

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Keywords

Fibrous Dysplasia, Monostotic, Polyostotic, GNAS1, cAMP.

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