Randomised Study of effectiveness of Dexamethasone in Reducing Post-operative Nausea and Vomiting in Laparoscopic Cholecystectomy Chatterjee Deepak1, Kumar Satendra1, Niranjan Ashutosh2, Srivastava Arati3, Dohare Sushil4 1Assistant Professor, General Surgery, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P. 2Professor, General Surgery, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P. 3Associate Professor, Anaesthesiology, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P. 4Associate Professor, Community Medicine, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P. Online published on 24 April, 2013. Abstract Introduction This study confirms the effectiveness of preoperative administration of Dexamethasone in reducing the incidence of post-operative nausea and vomiting (PONV) after laparoscopic cholecystectomy and simultaneously establishes the exact incidence. Methodology 202 patients who underwent laparoscopic cholecystectomy under general anaesthesia were studied in a randomized, double blinded, placebo-controlled study. The Test (Dexamethasone) Group (n=103) was given dexamethasone 8mg IV and the Control (Saline) Group (n=99) was given 0.9% saline 2 ml IV before transferring to the operation area. Operative and anaesthetic techniques were standardised for all patients. Results Post operatively 29.1% of the patients in the Dexamethasone Group compared with 47.5% in the Saline Group reported nausea (p=0.01). The incidence of vomiting in the Dexamethasone Group was 17.5% and in the Saline Group was 38.4% (p=0.001). Conclusion It was concluded that the incidence of nausea and vomiting after laparoscopic cholecystectomy was 47.5% and 38.4% respectively and the pre-operative administration of 8mg of dexamethasone IV significantly decreased the incidence of PONV. Top Keywords Laparoscopy Cholecystectomy, PONV, Dexamethasone. Top |