Pesticides: Deleterious Effects on Neurotransmission Joshi Gauri1,*, Joshi A.G.2, Sontakke Ajit3, Wingkar K.C.4, Mane Dhirajkumar5 1Ph. D. Student, Department of Physiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 2Professor, Department of Physiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 3Professor & amp; HOD, Department of Biochemistry, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 4Professor & amp; HOD, Department of Physiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 5Statistician, Directorate of Research, Krishna Institute of Medical Sciences “Deemed To Be University”, Karad, Maharashtra, India *Corresponding author: Gauri Joshi, PhD Student, Department of Physiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, Mobile No: - +91-9970177588 Email ID: jgouri123@gmail.com
Online published on 27 November, 2019. Abstract Introduction There is abundant use of chemicals in the environment for increasing the productivity and growth of crops which leads to million cases of pesticide poisoning every year. Pesticides mainly inhibit cholinesterase enzyme which results in excess accumulation of acetylcholine resulting in severe problems in nervous, reproductive, immune and endocrine systems in addition to various chronic diseases like cancer. Objectives To assess extent of derangement of inhibition of cholinesterase enzyme in pesticide sprayers of Satara District. Method In present study, 40 pesticide sprayers with age group of25-35 years were selected as subjects. 40 healthy farmers of same age, not involved in spraying activity were taken as control group. A detail history and anthropometric measurements of both groups were taken. Blood sample was collected in plain bulb and serum was separated out for the analysis of cholinesterase by DGKC method. To find out significance level, comparison of mean and SD of both groups was done by using Unpaired t test. Results There was highly significant decrease in serum AChE(P value < 0.0001) among pesticide sprayers as compared to control group. Conclusions To create awareness in pesticide sprayers, about hazardous effect of pesticides was main goal of the study. Top Keywords Pesticides, cholinesterase inhibition. Top |