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Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 4
First page : ( 381) Last page : ( 386)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00320.7

Compression of Efficacy of Topical Phenytoin, Honey and Combination of Honey with Triglyceride Tree Nitrate on Wound Healing in Rat

Ahmadinejad Mehdi1, Khaksarhaddad Mohammad2, Amirhasani Alireza Raji2, Khazaeli Payam3, AsadiShekari Majid4, Ahmadipour Maryam5, Tahmaseby Saba6,*

1Department of Anesthesiology, Kerman University of Medical Sciences, Kerman, Iran

2Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran

3Department of Pharmacology, Kerman University of Medical Sciences, Kerman, Iran

4Department of Histology, Kerman University of Medical Sciences, Kerman, Iran

5Department of Pediatric Cardiology, Kerman University of Medical Sciences, Kerman, Iran

6Department of Anesthesiology, Kerman University of Medical Sciences, Kerman, Iran

*Corresponding Author: Saba Tahmaseby, Department of Anesthesiology, Kerman University of Medical Sciences, Kerman, Iran

Online published on 27 November, 2019.

Abstract

Background

Drugs and many traditional medicine compounds have long been used to accelerate the wound healing process. We investigated the effect of honey and nitroglycerin on wound healing.

Materials and Method

The rats were randomly divided into 4 groups of Control, Nitroglycerin, Honey, and Phenytoin. After the injury of animals in each group, except for the control group, the dressings with related-drugs were opened-up daily. T he wound was accessed on days 1, 4, 8, 12, 16, and when it was completely healed. At the same time, a sample of wound was collected at each stage for histological examination.

Results

wound healing period in honey and nitro glycerin groups was significantly shorter than control and phenytoin groups. improvement in inflammation and epithelial formation, were not statistically significant.

Conclusion

It seems that honey and nitroglycerin cause faster wound healing. However, more studies are needed to investigate the effects of these drugs as well as their synergistic use on the wound.

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Keywords

Wound, honey, nitroglycerin, phenytoin.

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