Effect of Follicular Activin a and Granulocyte Macrophage-Colony Stimulating Factor on the Prediction of Pregnancy Rate Following Intracytoplasmic Sperm Injection in Women with PCOS Shukry Nagham T.1,*, Al-Dujaily Saad S.2 1High Institute of Infertility Diagnosis and ART, Al-Nahrain University, Baghdad-Iraq 2Biotechnology Research Center, Al-Nahrain University, Baghdad-Iraq *Corresponding author Nagham T. Shukry, e-mail: naghamsukry5@gmail.com
Online published on 27 November, 2019. Abstract Polycystic ovary syndrome (PCOS) is a reproductive endocrinopathy of obscure etiology, and it is regarded as a complicated disorder, Activin A is one member of the transform growth factor-superfamily (TGF), which has a role in stimulating the synthesis, and secretion of FSH. The Granulocyte macrophage-colony-stimulating factor (GM-CSF), is act as important mediator for inter-cellular communications, and has effects in the process of the implantation. The goal of present study is to elucidate the effects of both activin A hormone and GM-CSF on implantation and successful pregnancy of embryos developed after ICSI. The study was enrolled eighty-eight women that classified according to the cause of infertility into 38 women without PCOS (because of male factor) and 50 women diagnosed as PCOS through the period from Nov.2016 till April 2018. All women were undergoing intracytoplasmic sperm injection procedure (ICSI). Activin A and GM-CSF in the follicular fluid were measured in all women participating in the study, and the β-HCG test was done 12–14 days after embryo transfer. The results of this work found that activin A and GM-CSF levels in the follicular fluid were higher in women with PCOS, when compared to their levels in the control (non-PCOS) women and the levels were higher in pregnant women with PCOS and these results may be useful to be used the activin A and GM-CSF as predictors of the successful process of implantation and pregnancy. Top Keywords Activin A, GM-CSF, FF, ICSI, PCOS, pregnancy rate. Top |