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Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 4
First page : ( 666) Last page : ( 671)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00369.4

Immunohistochemical expression and enumeration of mast cells in synovial tissue from Iraqi patients with Rheumatoid arthritis

Jassim Ola A.1, Al-Sharqi Sahar A. H.1, Wahab Mahmood Shihab2

1Dep. of Biology, College of Science, Musatnsirihya University, Baghdad, Iraq

2Nursing Home Hospital, Medical City Complex, Baghdad, Iraq

Online published on 27 November, 2019.

Abstract

Rheumatoid arthritis (RA) is one of chronic autoimmune disease leading to extensive changes of the joint resulting in cartilage damage and bone erosion. The present study focuses on some immunohistochemical and change in knee of the patients in RA hematological and in patients and control. Synovial membrane biopsies were taken from 30 knees of RA patients during total knee replacement. Immunohistochemical staining for CD117 and alcian blue-safranin staining techniques were used to evaluate density and expression of mast cells. In addition, blood sample were obtained from 30 RA patients and 20 controls for hematological study. Immunohistochemical study shows increase in mast cell numbers and also increase in CD117 mast cell, also there was significantly decrease (p˂ 0.05) in the count of lymphocytes and monocytes in RA patients group compared to healthy controls groups Although, there was signification elevation (p˂ 0.05) in erythrocytes sedimentation rate (ESR) in RA patients group compared to healthy controls groups.

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Keywords

Rheumatoid arthritis, Mast cell, CD117, knee joint.

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