Antimicrobial Activity and Molecular Modeling Study of Schiff Base Derived from Sulfamerazine Othman Rasha M.1, Al-Masoudi Wasfi A.2, Hama Adil A.3, Hussain Sara M.1 1Department of Microbiology, College of Veterinary, University of Basrah, Iraq 2Department of Physiology, Pharmacology and Chemistry, College of Veterinary, University of Basrah, Iraq 3Department of Anaesthesia, College of Health and medical technology, Middle Technical University, Baghdad, Iraq Online published on 27 November, 2019. Abstract Condensation of 4-amino-N-(4-methylpyrimidin-2-yl)benzene sulfonamide (Sulphamerazine Drug) with 1, 3-Benzodioxole-5-carbaldehyde (Piperonal)yielded Schiff base derivative in good yield. Spectroscopic characterization such as, IR and NMR of synthesized compound have been obtained by using nuclear magnetic resonance 600 MHz. The synthesized compound was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus and klebsella pneumonia and fungicidal activity against Candida albicans, Candida trobicalis, Candida krusi, Aspergillus fumigatus and Aspergillus niger. A new compound exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions. Top Keywords Sulphamerazine, Piperonal, Schiff-base, Microbial activity, Molecular modeling. Top |