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Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 4
First page : ( 939) Last page : ( 945)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00419.5

Immune Modulation as A Result of Helminthes Infestation in Patients with Idiopathic Inflammatory Disease, Crohn's Disease and Ulcerative Colitis: Cases Control Study

Ali Ghada Basil1,*, Muslim Osamah Tahir1, Abbas Abbas Ghafil2

1Assit.prof. College of Medicine, University of Qadissya, Iraq

2Ph. D. Student College of Medicine. University of Qadissya, Iraq

*Corresponding author: Ghada Basil Ali, Assit. Prof. College of Medicine. University of Qadissya, Iraq

Online published on 27 November, 2019.

Abstract

The UC and Crohn's disease are chronic, idiopathic, inflammatory diseases of the GIT that share common symptoms such as diarrhea, abdominal pain, fever, and weight loss. Ulcerative colitis involves all or part of the colon, whereas, Crohn's disease commonly involves the terminal ileum and proximal colon. The two major forms of IBD share many clinical and epidemiological characteristics, suggesting that underlying causation may be similar. Yet, UC & Crohn's disease are distinct syndromes with divergent treatment and prognosis. Aim of the study: Study a relationship between some parasitic infections such as helminthes infestation, and the development of IBD. Understanding the correlation between parasitic infections and autoimmune disorders may be helpful in prediction, early identification and conceivably the prevention of these diseases. The current study also showed immunological evidence that helminthes can modulate host immune response to prevent and minimize the inflammatory response in cases of IBD through increasing the level of anti-inflammatory cytokines and decreasing the level of pro-inflammatory cytokines. The combined infestation with multiple intestinal helminthes has a better protective role than single parasite in protection against inflammatory bowel disease.

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Keywords

Crohn's disease, ulcerative colitis, IL1B and IL10, IBD.

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