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Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 4
First page : ( 1172) Last page : ( 1178)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00459.6

Angiopoietin-like protein-2 and IL-17 Association with Liver Fibrosis in Patients with Chronic Hepatitis B

Jabar Shehab A.1, Abdulsattar Sura A.1, Alwaisy Safaa A.A. Razzak2

1Department of Chemistry and Biochemistry, College of Medicine, Mustansiriyah University, Iraq

2Gastroenterology and Hepatology Teaching Hospital, Iraq

Online published on 27 November, 2019.

Abstract

Hepatitis is an inflammation of the liver with condition can be self-limiting or can progress to fibrosis (scarring), cirrhosis or liver cancer. Angiopoietin-like protein 2 (Angptl2) is a mediator of chronic inflammation that contributes to extracellular matrix remodeling. This study aims to explore the predictive value of Angptl2 as a novel biomarker of liver histology and evaluate the association of Angptl2 and IL-17 with the degree of liver fibrosis. Hepatitis B patients with normal to minimally raised ALT were recruited. Serum Angptl2 and IL-17 levels were detected by using commercial ELISA kit. Liver histology was evaluated by the Ishak scoring system. A highly significant increase of ANGPL2 and IL-17 were observed in sera of chronic hepatitis B patients in comparison to that of control group, while non-significant increases of ANGLP2 and IL-17 with fibrosis stages in chronic hepatitis B were indicated. Angptl2 and IL-17 were found to be increased with increasing degrees of liver fibrosis. This suggests that ANGPL2 and IL-17 may not only induce the inflammation, but also contribute to disease progression of fibrosis and chronicity.

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Keywords

Fibrosis, IL-17, Angiopoietin-like protein 2, hepatitis and liver.

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