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Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 4
First page : ( 1371) Last page : ( 1376)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00493.6

Antiurolithiatic Activity of the Plant Extracts Ofannonaon Ethylene Glycol Induced Urolithiasis in Rabbits

Al-Bajari Shihab A.1, Younis Huda A., Raoof Sama A.1

1Mosul Technical Institute, Northern Technical University, Mosul, Iraq

Online published on 27 November, 2019.

Abstract

Ethylene glycol (EG)is a colorless, odorless, sweet-tasting chemical mainly used as antifreeze which is fatal if ingested. Annonais used as spices and as an herbal medicine (antioxidant) in America countries. Aim of the research was to evaluate the protective role of annonaceae against the Ethylene glycol as toxicity in rabbits. Twenty fiverabbits were divided into five groups: (GI, control group) 5rabbitsuntreated with Ethylene glycol and(GII) 5rabbits were give 0.75% Ethylene glycol in drinking water onlyfor 30 days, while (GIII, GIV and GV)15 rabbits were give 0.75% Ethylene glycol in drinking water and oral supplementation of Annona (flavonoids, glycosides and alkaloids) extracts(100mg/kg Bw) two times daily for 30 days. Blood samples were collected (plain tube & EDTA tube) to clinical examination. EG induced significant reduction (20%) in rabbits BW in G II in comparison with GI, GIII, GIV and GV. The result show, AST, ALT, ALKP, TBIL, MDA, SOD, urea, creatinine, globulin and monocytesin G II were significantly elevated (P=0.05); meanwhile there were significant decrease (P=0.05) in total protein, albumin, A/G ratio, Gpx, CAT, GSH, BP, Hb, WBC and RBC. But after treatment by extracts of Annonasignificant reduction in AST, ALKP, TBIL, MDA, urea, creatinine and monocytes, while SOD, ALT no significant decrease. Meanwhile there were significant increase (P=0.05) in total protein, A/G ratio, Gpx, GSH, BP, Hb, WBC and RBC.

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Keywords

Annona, Ethylene Glycol, Toxicity, Blood, Liver and kidney markerenzymes, Antioxidants, Oxidative stress.

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