Investigation of DNA Changes in Chronic Myeloid Leukemia (CML) Patients Using Molecular Techniques Lafta Haider Y1, Allami Risala H2, Zayer Nayama H1, JMutter Amel1, Juma Mahdi Ch1 1Ministry of Science and Technology, Central Labs. Directorate, Al-Nahrian University, College of Biotechnology, Iraq 2Al-Nahrian University, College of Biotechnology, Iraq Online published on 27 November, 2019. Abstract Modern molecular techniques were used to identify the damage of DNA molecule. In this study, a high-precision technique was used to identify other genetic changes that lead to cellular changes at the molecular level causing damage and changes to the DNA molecule. We have used complete sequencing technique and information management to compare these markers although we have identified many new forms and differences in genes for chronic myeloid leukemia patients. Those differences that can be identified were easily disaggregated by a simple fractionation of the sequence polymerization reactions (PCR) of NOTCH4 and FAM46A, genes. In addition, the presence of these differences were also assessed in about 30 patients and compared the results with 10 samples of healthy at the end of abstract authors should mention what they are come with conclusion from this work. Top Keywords Whole exome sequencing, Chronic Myeloid Leukemia, Bioinformatics analysis, PCR reactions. Top |