Prevalence of Autoantibodies and the Clinical Spectrum of Disease in an Indian Patient Subpopulation with Lichen Planus Nikam Balkrishna Pralhadrao1,*, Chavan Dhanraj D.2, Shrivastava Nischhal2, Narkhede Namita2 1Assistant Professor, Department of Dermatology, Krishna Institute of Medical Sciences Deemed to be University, Karad 2P.G. Resident, Department of Dermatology, Krishna Institute of Medical Sciences Deemed to be University, Karad *Corresponding Author: Dr. Balkrishna Pralhadrao Nikam, Assistant Professor, Department of Dermatology, Krishna Institute of Medical Sciences Deemed to be University, Karad
Online published on 23 December, 2019. Abstract Background Lichen planus is a chronic mucocutaneous inflammatory disease which frequently involves the oral mucosa. The present study was conducted to assess prevalence of auto antibodies and clinical spectrum of lichen planus. Materials & Method The present study was conducted on 82 patients of lichen planus of both genders. A thorough clinical examination was performed. 5 ml of blood was drawn in a sterile syringe with all aseptic precautions. Antibodies including anti-nuclear antibody, anti-desmoglein 1 antibody, anti-desmoglein 3 antibody, anti-keratinocyte antibody, anti-mitochondrial antibody and anti-thyroglobulin antibody were assayed in serum samples by indirect immunofluorescence according to commercially available testing kits. Results Out of 82 patients, males were 24 and females were 58. Age group 11–20 years had 5 males and 15 females, 21–30 years had 8 males and 26 females, 31–40 years had 6 males and 10 females, 41–50 years had 3 males and 4 females and > 50 years had 2 males and 3 females. The difference was significant (P < 0.05). ANA was positive in 14, DSG-I in 15, DSG-III in 24, AKA in 27, AMA in 45 and TGA in 32. The difference was significant (P < 0.05). Conclusion Authors found that most common auto-antibodies found was AMA, AKA and DSG-III. Top Keywords Auto-antibodies, Desmoglein, Lichen planus. Top |