Correlation between Neutrophil-Lymphocyte Ratio and Proteinuria in Diabetes Shetty Meenakshi1, Hussain Mohammed Ahmed2, Jeganathan Jayakumar1,*, Pavan M.R.1 1Associate Professor, Department of Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Karnataka, India 2Resident, Department of Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Karnataka, India *Corresponding Author: Dr. Jayakumar Jeganathan Ph: 9343351015 e-mail: jayakumar.j@manipal.edu
Online published on 23 December, 2019. Abstract Introduction To study the relationship between Neutrophil-lymphocyte ratio and proteinuria in diabetes. Materials and Method This was a cross sectional study 196 diabetic subjects. They were divided into no nephropathy, incipient nephropathy and overt nephropathy. The Neutrophil lymphocyte ratio was compared between the three groups using Mann Whitney U test. Pearsons correlation was used to compare the other parameters between the three groups. Results There was significant difference between the median Neutrophil lymphocyte ratios in the three groups. The median NLR in patients with ‘no nephropathy’ was 2.69 (1.64–2.53). In patients with ‘incipient nephropathy’ was 2.77 (1.81–4.65). In patients with ‘overt nephropathy’ was 3.77 (2.01–5.39). A value of 2.752 of NLR can be taken as a cut off for predicting Overt Nephropathy with 74% sensitivity and 50% specificity. Conclusion Being a commonly available and cheap test, NLR can be advocated as a useful screening test in diabetics to predict the development or presence of diabetic nephropathy. Top Keywords Neutrophil, lymphocyte, Ratio, diabetes mellitus, nephropathy. Top |