Taste, Taste Receptors and Role of GLP-1 Signaling in Taste Perception Srikantaiah Vidya C1, Pereira Pratibha2, Kumar Divya P.3, Santhekadur Prasanna K.3, Priya D. Sai4, Sindhu R.4, Mahalakshmi Arehalli M.5,* 1Associate Professor, Department of Anatomy, CGC Research Group Member, JSS Medical College 2Professor, Department of Medicine, CGC Research Group Leader, JSS Medical College 3Associate Professor, Department of Biochemistry, Center of Excellence in Molecular Biology & Regenerative Medicine, JSS Medical College 4Post Graduate Students, Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 5Lecturer Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru *Corresponding Author: Arehalli M. Mahalakshmi Lecturer, Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India, e-mail: ammahalakshmi@jssuni.edu.in
Online published on 23 December, 2019. Abstract Balanced diet and proper healthy nutrition, avoidance of consuming high calorie or junk food or ingesting toxic substances that are harmful to the body and maintenance of physiological energy homeostasis are very crucial for all living organisms including human beings. After every food ingestion brain gets sensory signal from gustatory receptors and segregates and evaluates the stimuli based on the individual taste, leading to the personalized experience very commonly known as flavor. There are five very well-known taste qualities such as sweet, salty, bitter, sour, and umami. The production of physiologically important incretin hormone Glucagon like peptide-1 (GLP-1) in the taste perception cells and the presence of its known receptor GLP-1R on adjacent taste nerve fibers evidently suggest that GLP-1 signaling is associated with the function of taste. In this brief review, we will provide a bird eye view on the recent advance in taste, taste receptors and GLP-1 signaling and we will discuss their pivotal role in overall taste perception and signaling. Top Keywords Taste, Sweet, Sour, Umami, GLP-1. Top |