Antifungal Sensitivity of Candida Sp. Isolated from Skin Infections at a Tertiary Care Teaching Hospital Das Chandan1, Dhar Shrikant Kumar1, Behera Debasmita2,* 1Associate Professor, Department of Medicine, IMS and SUM Hospital, Siksha “O” Anusandhan, K8, Kalinganagar, Bhubaneswar, Odisha, India 2Assistant Professor, Department of Skin and VD, IMS and SUM Hospital, Siksha “O” Anusandhan, K8, Kalinganagar, Bhubaneswar, Odisha, India *Corresponding Author Dr. Debasmita Behera Assistant Professor, Department of Skin and VD, IMS and SUM hospital, Siksha “O ”Anusandhan, K8, Kalinganagar, Bhubaneswar-751003, Odisha, India e-mail: drdbehera427@gmail.com
Online published on 23 December, 2019. Abstract Objective In this study, we have found the prevalence Candidal Sp. in skin infections of the patients attending at the department of medicine and Skin and VD. We have also evaluated the drug sensitivity patterns of identified Candida sp. Method This prospective, cross-sectional study was conducted at the IMS and SUM hospital from January 2016 to February 2017, and comprised the causative organisms foe skin infections. Species differentiation was confirmed by specific culture medium method. Antifungal susceptibility of isolated Candida species were evaluated with disc diffusion method. Results of the 219 Candida isolates, majority of them were isolated from the department of skin and VD 78(35.6%) and Medicine department 59(26.9%). Moreover, 144(65.8%) samples were of females and 75(34.2%) were of males. Candida albicans 128(58.45%) was the most predominant species followed by Candida glabrata 30(13.69%), Candida tropicalis 26(11.87%), Candida krusei 17(7.76%), Candida parapsilosis 12(5.47%), Candida dubliniensis 3(1.37%) and Candida lusitaniae 3(1.37). All isolates were least susceptible to amphotericin B with a susceptibility rate of 213(97.26%). The highest resistance was found for voriconazole 40(18.26%) compared to fluconazole 32(14.61%). Conclusion Candida species were resistant to many antifungals and in this study it is revealed that Amphotericin B is the most sensitive antifungal for skin infections. Top Keywords Candida albicans, Non-albicans (NAC), Antifungal sensitivity test, CHROMagar Candida. Top |