Expression of APOBEC3H Isoenzyme on the Level of Protein in Breast Cancer Patients Moatasam Rebaz1,*, Kayani Kamaran2 1MSc Student, Department of Medical Microbiology, Faculty of Health and Science, Koya University, Koya 2Assistant Professor, Department of Chemistry, College of Science, University of Salahaddin-Erbil, Iraq *Corresponding Author: Rebaz Moatasam, Department of Medical Microbiology at Koya University, Koya-Erbil, Iraq, e-mail: rebaz.muhtasm@koyauniversity.org, Phone Number: 009647503313340
Online published on 23 December, 2019. Abstract Breast Cancer is a disease that results from the alteration of the cellular genome in breast tissue and can lead to the second cause of cancer death in human so that it is an object of intensive research. APOBEC3H is a member of APOBEC3 sub-family of DNA cytosine deaminases, which have evolved as a crucial role of innate immune defense and have been contributing to cancer development throughout genetic mutations. Eighty subjects were conducted to this study, forty subjects for each breast cancer patients and healthy group. Blood samples were analyzed for this study. After clotting blood sera were used to determine the quantity of APOBEC3H protein by Elisa technique. This study demonstrates that APOBEC3H expression on the level of protein is significantly down-regulated in breast cancer patients compared to that of a healthy group. This study reveals that the APOBEC3H expression on the level of protein can be used as a potential biomarker for predicting breast cancer with the significant high value of AUC. Top Keywords APOBEC3H, biomarker, breast cancer. Top |