Serum Levels of Oxidative Stress Biomarkers in Patients Obsessive Compulsive Disorder in Tikrit City, Iraq Mohammed Mohammed Amer*, Hilal Nihad Nejres, Ani Ahmed Hashim Al Ass. Prof., M.B. Ch. B.F.I.B.M.S, Department of Pathology, College of Medicine, Tikrit University, Department of Pediatric, Salahdine, Iraq *Corresponding Author: Mohammed Amer Mohammed, Department of Biochemistry, Clinical analysis, Salahdine General Hospital, Salahdine, Iraq, e-mail: moh040578@gmail.com, Phone: 00964-7719330585
Online published on 23 December, 2019. Abstract Background Obsessive-compulsive disorder (OCD) is one of the major disabling disorder affecting about 2% of the population, and it causes significant mental health costs. Aim: The purpose of this study is to determine the changes in serum levels of oxidative stress and the role of oxidative stress biomarkers in obsessive compulsive disorder (OCD). Materials and Method A cross-sectional controlled study was carried out in Salah Al-din City from 1st of February 2019, to 1st of June, 2019. The number of obsessive compulsive disorder 60 patients whose ages between 18–68 years old. These patients admitted to psychiatric unit at Salah Al-din Teaching Hospital. The control group who were match to the patients studied include 30 healthy control. Results The study showed that there is the significant difference between serum level of patients and the control groups. In this study showed that is high level of malondialdehyde (MDA), in patients in compare with control group and lower levels of antioxidant enzymes (GSH-PX, SOD1, CAT) of patients in compare with control group. Conclusion We can use serum level of some biochemical markers in compare between patients, and control with OCD. The relationship inverse between MDA and GSH-PX, SOD1, CAT, in patients and control groups. Top Keywords Obsessive compulsive disorder, Oxidative stress, Superoxide dismutase 1, Glutathione peroxidase, Catalase, Malondialdehyde. Top |