Estimation of Serum Level of Micro RNA 224 in Different Stages of Hepatocellular Carcinoma Semeda Nady Mahmoud1,*, Mohammed Hala Ibrahim1, Saad Zeinab Mostafa1, Soliman Wael1 1Tropical Medicine Department Faculty of Medicine, Minia University *Corresponding Author: Nady Mahmoud Semeda, MD, Tropical Medicine Department, Minia University, Egypt, e-mail: drnadysemeda@yahoo.com, Contact No.: 01005651501
Online published on 23 December, 2019. Abstract Background Hepatocellular carcinoma (HCC) is the fifth common cause of cancer iaround the world, and the third common cause of death related to cancer. miR-224 done an important role in cell proliferation, migration, invasion, and antiapoptosis in HCC by binding to its gene targets. So, miR-224can be used an important biomarker for predicting the aggressiveness of HCC. Aim of study to evaluate its role in predicting aggressiveness of HCC through detecting its level across different stages of hepatocellular carcinoma. Method An observational study, in Tropical Medicine Department, El-Minia University Hospital, El-Minia,-Egypt. Patients with hepatocellular carcinoma on top of HCV induced Liver cirrhosiscollected among the patients of tropical medicine department from January 2017 to January 2018. Patients were divided into 3 groups according to Barcelona classification of liver cancer (BCLC) into, group 1 with BCLC A, group 2 with BCLC B, group C with BCLC C, and control group of LC without HCC, for all groups: history, examination and routine investigations, abdominal ultrasound, Multislice CT scan and miR-224 assay were done. Results There was a significant difference between the level of miR 224 in different stages of hepatocellular carcinoma with the lowest level in BCLC A and the highest level in BCLC C with P value 0.001 indicating its role in predicting aggressiveness of hepatocellular carcinoma. Conclusion miR-224 could serve as a good prognostic biomarker for HCC, and can be used as a marker predicting aggressiveness of HCC. Top Keywords LC. Hepatocellular carcinoma.miR-224. Top |