Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 1174) Last page : ( 1178)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.02988.7

Histopathological Changes of Mice Immunized by Serratia Marcescens Whole Cell Sonicated Antigens

Mohammed Nasr T.

College of Veterinary Medicine, University of Baghdad, Iraq

Online published on 23 December, 2019.

Abstract

The research was designed to prepare sonicated antigen of Serratiamarcescens and evaluate its histopathological effect of mice organs which include (liver, spleen, lung and kidney). For this purpose, 24 mice randomly divided into four groups. The first group was immunized with killed whole cell sonicated Serratiamarcescens (KWCSA-SM) (1000 μg/ml) subcutaneously. Second group was immunized with killed whole cell sonicated S.marcescens(KWCSA-SM) (500 μg/ml) subcutaneously. Third group was immunized with whole cell S.marcescens (1000cfu/ml) subcutaneously, 4th group was injected by P.B.S.(pH7.2) as negative control group. Histopathological changes many showed differences between the first group which characterized by sever lesion and other immunized groups, compared with the control group which showed mild lesion in their organs which include severe mononuclear cells infiltration in the interstitial tissue with acute cellular degeneration of epithelial cells.

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Keywords

Serratiamarcescens, Antigens, Histopathlogical changes, Mice.

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