Prevalence of Helicobacter Pyloriin Children with Type 1 Diabetes Mellitus and its Association with C-peptide and HbA1c AL-Azzawi Thanoon Yahya1, Abood Ahmed Sattar1,*, AL-Awady Mohammed Shaker2 1Departmet of Biology, College of Education, Al-Iraqia University 2The Specialized Center for Endocrinology & Diabetes *Corresponding Author: Dr. Ahmed Sattar Abood Ph. D. Clinical Immunology e-mail: Alwazeer81@yahoo.com
Online published on 23 December, 2019. Abstract Background Helicobacter Pyloricauses gastrointestinal tract infection as well as Extra-gastric disorders with increased infection rates in developing countries. It was recently observed that these bacteria may increase their prevalence in patients with diabetes mellitus type 2. Aims Therefore, the present study aimed to find out the prevalence H. pylori in DMT1 in children, and its association with C-peptide and HbA1c. Patients and Method A total of (204) samples 91 male (44.6%)and 113 female (55.4%) were collected form type 1 diabetic children with age range (1–15) years from the Specialist Center for Endocrinology and Diabetes, Ibn Al-Baladi Hospital for Children and Women. Ethical consent and case history were obtained from parents according predesigned questionnaire. Chromatographic immunoassay rapid test was used to detect H. pylori infection seropositivity and the immunoassay analyzer cobas e411 was used for HbA1c and C-peptide. Results H. pylori seropositivity 61(30%) cases out from total 204 type 1 diabetic case. The C-peptide results showed significant differences between H. pylori positive and negative groups (p=0.023). Significant differences were found among the H. pylori positive, negative type 1 diabetic cases and apparently healthy in both HbA1c and C-peptide (p ≤0.001).in addition, significant positive relationship between the H. pylori infection and C-peptide (Pearson correlation= 0.663 p≤0.001). Conclusion This study concluded that there is association between H. pylori infection and C-peptide in type 1diabetic children. Top Keywords Helicobacter pylori, Type 1 diabetes mellitus, Children, C-peptide and HbA1c. Top |