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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 1308) Last page : ( 1313)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03014.6

Genotoxic and Teratogenic Effects of Mycophenolate Mofetil in Mice

Sadeq Wajdi Sabeeh1, Neama Ruida Watheq1,*

1Biology Department, College of Science, Tikrit University, Iraq

*Corresponding Author: Ruida Watheq Neama, Biology Department, College of Science, Tikrit University, Iraq e-mail: wajdialsadek@gmail.com

Online published on 23 December, 2019.

Abstract

Mycophenolate mofetil (MMF) or cellcept is an immunosuppressive drug which used to suppress immune system activity and reduce the risk of organ rejection in transplant patients. The present study investigates the cytotoxic, genotoxic and teratogenic potential of MMF in white mice. Genotoxic effects of this agent were evaluated using micronucleus test, and skeletal malformations were investigated according to dose concentration as treatment was with 16.6 mg. kg−1 and 33.3 mg. kg−1 MMF. A significant difference was observed in MNiPCEs in both treated groups than negative control, and 33.3 mg. kg−1 concentration showed significant differences in MNi than negative control. A significant malformation was found in abnormal bones of cranial, ribs, pelvic girdle and shoulder girdle bones in 16.6 mg. kg−1 cellcept group, while there were no significant differences in bone total number. There was a high difference in bones total number of thoracic and neck vertebrae of 33.3 mg. kg−1 treatment, while a high significant show in abnormal bones of thoracic, neck, tail, sacral and lumbar vertebrae in 16.6 mg. kg−1 group. In conclusion, MMF has cytotoxicity and/or genotoxicity action it possesses a high teratogenic potential, these effects increase with increasing dose.

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Keywords

MMF, Teratogenic Effects, cellcept.

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