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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 1545) Last page : ( 1549)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03058.4

Vitamin D Receptor Gene Polymorphism Fok 1 and Vitamin D (25-OH)D Status in Type 2 Diabetes Mellitus Patients with Pulmonary Tuberculosis

Wahiduddin1,2, Pranoto Agung3,4, Sudjarwo5, Mertaniasih Ni Made6

1Doctorate Degree in Medical Education, Postgraduate Programme, Faculty of Medicine, Universitas Airlangga

2Department of Epidemiology, Faculty of Public Health, Universitas Hasanuddin

3Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga

4Dr. Soetomo Teaching Hospital, Surabaya

5Department of Chemical Pharmacy Faculty of Pharmacy, Universitas Airlangga

6Department of Clinical Microbiology, Faculty of Medicine, Universitas Airlangga

Online published on 23 December, 2019.

Abstract

Vitamin D plays a role in supporting macrophage activation via vitamin D receptor. Polymorphism of Fok1, vitamin D receptor gene, can show the different level of susceptibility to pulmonary tuberculosis (PTB). This research aimed to analyze the comparison of polymorphisms of the Fok1region of the vitamin D receptor (VDR) gene and vitamin D status in patients with type 2 diabetes mellitus (T2DM) with PTB. A descriptive comparative study of adult T2DM patients seeking treatment at the endocrine clinic, internal medicine clinic, and pulmonary clinic in two government hospitals in the city of Surabaya. The result showed that F allele frequency (63.3%), f allele (36.7%), FF genotype variation (40.0%), Ff (46.7%) and ff (13.3%) in T2DM group with PTB while in T2DM group without PTB obtained frequency of F allele (54.8%), f allele (45.2%), variation of FF genotype (33.3%), Ff (46.7%) and ff (20.0%). Polymorphism in T2DM group with PTB (60.0%) and DMT2 group without PTB (66.7%). Plasma vitamin D levels were found median (IQR) 20.26 (0.78) ng/ml in the T2DM group with PTB and 20.18 (1.25) ng/ml in the T2DM group without PTB. There were no differences in polymorphism in the frequency of F and f alleles, FF genotype variations, Ff, ff in the Fok1 region of the VDR gene, and the average vitamin D level between T2DM patients with and without PTB. Further research is needed on the linkages and gene interactions encoding macrophage activation proteins.

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Keywords

Fok1 region polymorphism, vitamin D level, type 2 diabetes mellitus, pulmonary tuberculosis, PCR-RFLP, DNA Sequencing.

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