The Effectiveness of the Use of Propolis toward the Number of Polymorphonucleas Cells in Mice Wounds Horax Shaerly1, Achmad Harun1, Dewi Nurmala2 1Department of Pedodontic, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia 2Student of Dentistry Faculty, Hasanuddin University Online published on 23 December, 2019. Abstract Background Propolis is a honey bee product with a very complex chemical composition, made by gummy and balsamic materials collected by bees from sprouts, flower buds, trees and other vegetal-tissue resinous trees. Propolis is useful as an antibacterial, antifungal and anti-inflammatory. During inflammation, polymorphonuclear migration to the wound area increases and propolis acts to suppress the amount of polymorphonuclear in the wound. Objective To know the effectiveness of propolis to decrease the migration of polymorphouclear neutrophil cells to the wound in mice. Method Experimental research with post-test only design with group control design. Propolis taken from the forest then made an extract with a concentration of 80% and then the mice were inserted with a wound depth of 2 mm and a wound length of 15 mm. Cut wounds of mice smeared with 80% propolis extract twice a day and then sacrificed 3 mice for check-up on days 1, 3, 5, and 7. Then histology was examined. Statistical analysis was performed by Mann Whitney test. Results There were significant differences between treatment groups and control groups. Conclusion Propolis extract with 80% concentration has an influence on suppressing the amount of polymorphonuclear migration to the inflammatory area. Top Keywords Propolis, Inflammation, Polymorphonuclear. Top |