(3.235.249.219)
Users online: 8981     
Ijournet
Email id
 

Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 2200) Last page : ( 2205)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03180.2

Anticancer Drugs as a Model for Destroying and Reducing the Growth of Human Breast MDA-MB231 Cancer Cells

Ali Hanan M.1,*, Mohsin Raghdan Hashim2, AlKinani Murtadha F. Hassan3

1Department of Chemistry, College of Education for Pure Sciences

2Animal Production, College of Agriculture, University of Basra, Iraq

3Department of Medical Laboratory Technology, Alkunooze University College, Iraq

*Corresponding Author: Hanan M. Ali, Department of Chemistry, College of Education for Pure Sciences, University of Basra, Iraq, Email: hanan1910@hotmail.co.uk

Online published on 23 December, 2019.

Abstract

Background

Azo dyes are receiving high attention in scientific research and they have great importance in chemical analysis. Cancer is a major public health problem in the world. Chemotherapy is one of the commonly-used strategies in breast cancer treatment. This therapy is usually associated with adverse side effects. The aim of current study was to produce a combination between Paracetamol and L-thyroxin drugs by synthesis of new pharmaceutical azo dye in order to reduce the growth of human breast MDA-MB231 cancer cells in vitro.

Method

The (S)-2-((4-acetamido-2-hydroxyphenyl) diazenyl)-3-(4-(4-hydroxy-3, 5-diiodophenoxy)-3, 5diiodophenyl)propanoic acid (1) was synthesised. The synthetic azo dye was derived from two different drugs (paracetamol and L-thyroxine). This azo dye was then characterized using m.p., UV-visible and IR spectrum.

Results

The synthetic azo dye provided non-toxic effects using different concentrations and it didn't show any haemolytic effect in the cells. Furthermore, the cell viability (cytotoxicity) assay presented the ability of azo dye in destroying and reducing the growth of human breast MDA-MB231 cancer cells.

Conclusion

The synthetic azo dye may be useful as a novel anticancer drug.

Top

Keywords

Azo dye, Cytotoxicity assay, Human breast cancer cells, Cell viability, conformational analysis.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
733,219,124 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.