Anticancer Drugs as a Model for Destroying and Reducing the Growth of Human Breast MDA-MB231 Cancer Cells Ali Hanan M.1,*, Mohsin Raghdan Hashim2, AlKinani Murtadha F. Hassan3 1Department of Chemistry, College of Education for Pure Sciences 2Animal Production, College of Agriculture, University of Basra, Iraq 3Department of Medical Laboratory Technology, Alkunooze University College, Iraq *Corresponding Author: Hanan M. Ali, Department of Chemistry, College of Education for Pure Sciences, University of Basra, Iraq, Email: hanan1910@hotmail.co.uk
Online published on 23 December, 2019. Abstract Background Azo dyes are receiving high attention in scientific research and they have great importance in chemical analysis. Cancer is a major public health problem in the world. Chemotherapy is one of the commonly-used strategies in breast cancer treatment. This therapy is usually associated with adverse side effects. The aim of current study was to produce a combination between Paracetamol and L-thyroxin drugs by synthesis of new pharmaceutical azo dye in order to reduce the growth of human breast MDA-MB231 cancer cells in vitro. Method The (S)-2-((4-acetamido-2-hydroxyphenyl) diazenyl)-3-(4-(4-hydroxy-3, 5-diiodophenoxy)-3, 5diiodophenyl)propanoic acid (1) was synthesised. The synthetic azo dye was derived from two different drugs (paracetamol and L-thyroxine). This azo dye was then characterized using m.p., UV-visible and IR spectrum. Results The synthetic azo dye provided non-toxic effects using different concentrations and it didn't show any haemolytic effect in the cells. Furthermore, the cell viability (cytotoxicity) assay presented the ability of azo dye in destroying and reducing the growth of human breast MDA-MB231 cancer cells. Conclusion The synthetic azo dye may be useful as a novel anticancer drug. Top Keywords Azo dye, Cytotoxicity assay, Human breast cancer cells, Cell viability, conformational analysis. Top |