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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 2335) Last page : ( 2340)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03206.6

Association of the 3’UTR188CT Polymorphism of Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 (LOX-1) Gene with Risk for Acute Coronary Syndromes in a Group of Iraqi Population

Alsadi Amal Abbas Hammoodi1, Albayatib Mohammed A. M.2, Hamid Moayed Basheer3,*

1Pharmacy, College of Pharmacy, University of Baghdad, Iraq

2PhD, Department of Chemistry and Biochemistry, Immunology and Molecular Biology, Al-Nahrain University, Iraq

3Department of Internal Medicine, FICMS, CABM. Al-Nahrain University, Iraq

*Corresponding Author: Moayed Basheer Hamid, Department of Internal Medicine, FICMS, CABM. Al-Nahrain University, Iraq, Email: qaisajam1981@gmail.com

Online published on 23 December, 2019.

Abstract

Background

Many study had tried to investigated the gene that associated with coronary heart disease and its complication, the danger of atherosclerosis and complication may increase as result of oxidization of low density lipoprotein by lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) which found as cell surface endocytosis searcher receptor, the aim is to explore whether or not the LOX-1 gene and it's 3’UTR C188T (rs1050283) polymorphisms were a genetic risks of ACS in sample of Iraqi population.

Method

A case control study in which 3`-UTR188 C/T single nucleotide polymorphism (SNP) of LOX1 were studied in 100 Iraqi subjects: 35 with ACS, 30 have chronic stable angina, and 35 control subjects without CAD. DNA amplification refractory mutant system polymerase chain reaction method was performed the genotyping.

Results

significantly not associated between 3`-UTR188 C/T SNP and the prevalence of ACS among the study groups.

Conclusion

3`-UTR188 C/T SNP polymorphism in the clinical practice not useful to evaluate the risk for ACS.

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Keywords

Acute coronary syndromes, Lectin-like oxidized low-density lipoprotein receptor-1 polymorphism, soluble LOX-1, 3`-UTR188 C/T (rs1050283) polymorphism.

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