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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 2345) Last page : ( 2347)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03208.X

Study the Activity of 14-3-3 Eta Protein among Ankylosing Spondylitis Patients

Al-Ma'amouri May Yahya1,*

1Department of Medical Laboratories Techniques, Technical Medical Institute of Mansur, Middle Technical University, Iraq

*Corresponding Author: May Yahya Al-Ma'amouri Department of Medical Laboratories Techniques, Technical Medical Institute of Mansur, Middle Technical University, Iraq, Email: may_yahya6@yahoo.com

Online published on 23 December, 2019.

Abstract

Background

Ankylosing spondylitis (AS) is an immune disorder that influence on spine and may affect on other joints. Ankylosing spondylitis occurs in patients under the age of 45 years, and result in disability and reduce the activity of patient if not treated sufficiently.

Objective

Measuring serum level of 14-3-3 eta protein among ankylosing spondylitis patients and evaluate its effectiveness in the diagnosis of disease.

Materials and Method

The study conducted in Al-Yarmouk teaching hospital and involved 40 patients with AS, 40patients suffer from rheumatoid arthritis (RA) and 20 healthy control. Mean ages were 38 ± 2, 43 ± 2 and 37 ± 2 for healthy control, rheumatoid patients and ankylosing patients respectively. We used ELISA test to estimate 14-3-3 eta protein levels and anti-citrullinate antibodies (ACP) in serum of ankylosing patients in addition to rheumatoid patients and control.

Results

Among 40 ankylosing patients, there were 18 females and 22 males, while rheumatoid patients there were 20 females and 20 males and control there were 10 females and 10 males. There was no significant in age and gender among studied groups, but there was highly significant in both ACP among rheumatoid patients higher than both ankylosing and control.

Conclusion

There is a relationship between 14-3-3 eta protein and both ankylosing spondylitris and rheumatoid arthritis, but with (RA) more than (AS), also there is relationship between ACP and (AS) and (RA), but also with (RA) more than (AS).

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Keywords

Ankylosing spondylitis, 14-3-3 eta protein, ACP, Rheumatoid arthritis.

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