Efficacy of Nano-Hydroxyapatite on Enamel Surface of Primary Teeth Following Exposure to Liquid Medications in Comparison with Sodium Fluoride: An in Vitro Study Hassan NM1,*, Jafar ZJ1 1Department of Pediatric & Preventive Dentistry, College of Dentistry, University of Baghdad, Iraq *Corresponding Author: Hassan NM, Department of Pediatric & Preventive Dentistry, College of Dentistry, University of Baghdad, Iraq, Phone: +964 770 062 8276, Email: dr.noor331986@gmail.com
Online published on 23 December, 2019. Abstract Background Demineralization initiated by acids is occasionally resulting from the intake of liquid medicines used to treat children on regular basis. Fluoride and nano-Hydroxyapatite has been broadly utilized in remineralization of erosive lesions. Aim To compare the efficacy of nano-Hydroxyapatite with sodium fluoride on enamel surface of primary teeth after exposure to pediatric liquid medications by investigating the topographical and weight changes. Materials and Method Thirty posterior primary teeth were extracted from (3–6) years old children. They were assigned to three groups: (A) nano-Hydroxyapatite, (B) sodium fluoride, and (C) artificial saliva (control). Groups A and B were exposed to pediatric liquid medications including: (Cephalexin and ParAzar). Afterwards, they were treated with 1% nano-Hydroxyapatite suspension and 2% sodium fluoride solution. The samples were examined for changes in surface roughness and weight using Atomic Force Microscope and an electronic balance respectively; at three periods: baseline, after 7 days of exposure to liquid medications, and 1 day of exposure to treatment agents. Results Group A showed a highly-significant difference in roughness for subgroups treated with nano Hydroxyapatite. A highly-significant increase in roughness was noticed for Cephalexin between baseline and treatment periods and a highly-significant reduction between baseline and ParAzar exposure periods. Regarding weight, a highly-significant difference was found for Cephalexin, and a significant difference for ParAzar after nano-Hydroxyapatite treatment. Conclusion 1% nano-hydroxyapatite suspension had the greatest remineralization efficacy when compared with 2% sodium fluoride solution. Top Keywords Nano-Hydroxyapatite, Sodium Fluoride, Cephalexin, ParAzar, Atomic Force Microscope. Top |