Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 2812) Last page : ( 2816)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03297.2

Cholinesterases Activities in Diabetic and Hyperlipidemic Patient

Mahmood Ahmed A.J.¹, Khalaf Musab M.², Zainal Adnan A.²

¹Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

²Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq

Online published on 23 December, 2019.

Abstract

This this study aims to find whether the elevation or the reduction of ChEs levels can be related to the diabetes mellitus and/or dyslipidemia. This study is considered as case-control comparative study. The human plasma and erythrocyte cholinesterase activity was tested in 5 group. Groups 1 and 2 were type 2 hyper-and normo-lipidemic diabetic patients respectively with good control of diabetes. Groups 3 and 4 were type 2 hyper-and normo-lipidemic diabetic patients respectively with inadequate control of diabetes. Group 5 included patient with hyperlipidemia only. The control group consisted of apparently healthy subjects with no history of diabetes or hyperlipidemia or exposure to anti-ChE insecticides or drugs. Also fasting serum glucose, HbA1c and the serum lipid profile were estimated in these groups. The results indicate that there is a relation between the BChE and diabetes, but no such relation could be seen with AChE. Also there is similar relation between the dyslipidemia and the both types of the ChE. The combination of inadequately controlled diabetes with dyslipidemia can cause elevation in both types of ChE enzyme but less than that of dyslipidemia alone.

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Keywords

Cholinesterases-Diabetes-Hyperlipidemia-AChE-BChE.

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