Topical Combination of Nifedipine with Lidocaine for Anal Fissure Treatment Albayati Rasha Kadim1, Al-Rekabi Adel Musa2, Alammar Nahedh R.2, Fawzi Hayder Adnan3,* 1Department of Surgery, Al-Diwaniyah Teaching Hospital, Al-Diwaniyah, Iraq 2Department of Surgery, College of Medicine, University of Al-Qadisiyah, Al-Diwaniyah, Iraq 3Clinical Pharmacy Departments, Baghdad Medical City Hospitals Campus *Corresponding author: Hayder Adnan Fawzi, Email: hayder.adnan2010@gmail.com
Online published on 8 March, 2019. Abstract Background A fissure consist of crack or tear in the vertical axis of the anal canal between the anal verge and the dentate line. Anal fissure is treated by two ways either medical or surgical treatment or both. Objective Evaluate the healing response of topical application of nifedipine with lidocaine in acute and chronic anal fissure Material and method A prospective study of one hundred patients presented with anal fissure to outpatient surgical clinic in Al-Diwaniyah teaching hospital, the patients divided into two groups, 40 patients (15 males and 25 females) with acute anal fissure, and 60 patients (25 males and 35 females) with chronic anal fissure. Results There was no statistically significant difference in the healing rate between acute and chronic lesion, however the rate of healed lesion in acute setting is higher than that of chronic setting (80% vs. 56%) Conclusion Topical application nifedipine and lidocaine effective in treating acute anal fissures with the healing response of 85%, and prevent evolution of acute anal fissures to chronic anal fissure. Top Keywords Acute, chronic, anal fissure, Medical treatment. Top |