The Effect of Hypercytokinemia in the Pathogenesis of Polycystic Ovary Syndrome in Iraqi Women Al-Shattawi Safa Sailh Mahdu1, Al-Jumili Essam Fadel1 1Biotechnology Dept. Genetic Engineering and Biotechnology Institute for Postgraduate Studies, University of Baghdad, Baghdad, Iraq Online published on 8 March, 2019. Abstract Polycystic Ovary Syndrome (PCOS) exists commonly among women in the reproductive age with an incidence rate of 3–15%. The clinical manifestations of PCOS include oligomenorrhoea, infertility and obesity. There is significant overlap of symptoms between PCOS and hypercytokinemia. The aim of this study was to investigate the prevalence of hypercytokinemia in PCOS patients. Materials and Method This was a cross-sectional study of clinically diagnosed 50 females with PCOS and another 50 age-matched females were studied as the control population. PCOS and Hypothyroidism were diagnosed by Ultrasound (US) and biochemical parameters IL6, TSH, T3 and T4. Results The mean IL6, TSH, T3 and T4 were significantly higher in women with PCOS as compared to healthy women controls. Conclusion PCOS is on the rise in hypothyroid patients. Identification of hypothyroidism may help us to treat and prevent fertility complications in PCOS females. Hypothyroidism needs to be early corrected in the management of infertility associated with PCOS which is of major concern these days. Top Keywords Polycystic Ovarian Syndrome, Thyroid Stimulating Hormone. Interleukin 6, Hypercytokinemia, Hypothyroidism. Top |