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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 2
First page : ( 773) Last page : ( 777)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.00388.7

Effects of Cefotaxime on Histopathological Changes in Rabbit Model of Infected Fractured Ulna

Saliem Ali H.

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq

Online published on 8 March, 2019.

Abstract

Background

Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, cefotaxime is a broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria. Current study was aimed to study the activity cefotaxime in bone healing process of infected fractured bone that is caused by Streptococcus pyogenes in rabbits.

Methods

Current study was performed on rabbit model of ulnar fracture after inducing infected transverse diaphyseal ulnar fracture using pathogenic Streptococcus pyogenes (0.025ml from 2.7 ×106cfu/ml) directly and healing activity after inducing non-infected fracture cefotaxime in the rabbit ulna directly. This experiment involved 30 rabbits divided into three groups (ten rabbits for each).

Results

The results showed that the administration of 0.5gm cefotaxime had reduced the symptoms of infection and succeeded in treating osteomyelitis or reducing Streptococcus pyogenes in the infected rabbits, prevented infection and promote fracture healing.

Conclusion

Cefotaxime is highly effective for treating bone fractures infected with Streptococcus pyogenes with good properties of bone fracture healing.

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Keywords

Cefotaxime, histopathology, ulnar fracture, osteoblast, macrophages, growth factors.

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