Study of Serum Antioxidants, Trace Elements and Leptin Levels in Epilepsy Patients Al-Bajari Shihab A1, AL-Lehebe Nashwan I2, AL-Alsadoon Labeeb H.1 1Mosul Technical Institute, Northern Technical University, Mosul, Iraq 2Department of Chemistry, College of Education, University of Mosul, Mosul, Iraq Online published on 8 March, 2019. Abstract Background Epilepsy is a set of chronic neurological disorders characterized by seizures. Nearly 90% of epileptic patients are found in developing countries. Epileptic seizures result from abnormal, excessive or hyper synchronous neuronal activity in the brain. The aim of the study was to monitor the changes in leptin level, trace elements and enzymatic antioxidants (glutathione peroxdiase (GPx), superoxide dismutase (SOD) and Catalase (CAT) as well as glutathione (GSH) and Malondialdehyde (MDA) as oxidative stress marker in epilepsy patients after treatment with Depakine. Method The total number of subjects included in this study was 30 epilepsy patients compared with 35 normal healthy controls. The two groups were compared in light of the measured variables. Results The results showed a significant decrease (P<0.05) in concentrations of GPx, SOD and GSH in comparison with normal control group; whereas significant increase (P<0.05) in leptin level and MDA concentration compared with normal control group. In addition, the results of trace element showed a significant decrease (P<0.05) in concentrations of Zinc, Copper and Selenium; whereas did not observe significant differences (P<0.05) in, iron, Magnesium and Nickel concentrations compared with normal control group. Conclusion The data of the present study suggested that oxidative stress marker and serum leptin levels seem to reflect diseased activity in epilepsy patients who use Depakine as a treatment. Top Keywords Epilepsy, trace elements, enzymatic antioxidants, leptin hormone, depakine, SOD, Catalase. Top |