Histopathological Changes in Testis Tissue Induced by Different Doses of Diclofenac Sodium in the Male Rats Al-Nahi Alaa Shakir1, Nasir Afyaa Sabah2 1Department of Biology, Faculty of SciencesUniversity of Kufa, Najaf, Iraq 2Department of Ecology, Faculty of SciencesUniversity of Kufa, Najaf, Iraq Online published on 8 March, 2019. Summary Background Non-steroidal anti-inflammatory drugs (NSAIDs) are prominent amongst the most generally endorsed solutions for extensive variety of musclo-skeletal (MSK) tissue disorders. Additionally, different NSAIDs, apart from diclofenac, may cause gastrointestinal ulceration, extreme harm in testis, renal, liver tissues and serious hematological problems. The aim of current study was to study the influence of diclofenac sodium in the male rat fertility. Method This study involved 20 rats divided into four groups, each of five rats, as control and three active groups. The latter were treated with intramuscular diclofenac (50, 100 and 150mg/kg body weight) for 21 days. Results The results showed a significant (p<0.05) decrease in rats’ testes weights as compared with controls. In addition, testes from diclofenac-treated rats showed variable dose-dependent pathological changes that were revealed under light microscopy. Conclusion Pathologically testicles damage related with NSAIDs isn't pervasive, however, we think it is interesting to report these findings for the recognition of the histopathological changes over the duration of diclofenac cytotoxicity. Top Keywords Diclofenac sodium, male rats, testis, Sertoli cells, spermatogenesis, infertility. Top |