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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 3
First page : ( 337) Last page : ( 342)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.00514.X

Role of serum Leptin and Prolactin in Iraqi females’ patients with Rheumatoid Arthritis

Joda Abbas Toma

Consultant [Med. and Rheum], AL-Mustansiriya Collage of Medicine, MBChB, F.I.B.M.S (med.) Rheum

Online published on 20 March, 2019.

Abstract

Leptin is an adipocyte peptide hormone that is important in preventing obesity by affecting the hypothalamus. Recent studies showed that leptin plays an important role in T lymphocyte responses, modulates inflammatory and immune responses.

This study was evaluating serum leptin and correlation between leptin level with disease activity and duration.

Patients were recruited from rheumatology out-patients clinic at Al-Yarmouk teaching hospital from the period from January to November 2017. A 95 subjects were recruited (70 patients and 25 healthy controls). The serum leptin and prolactin level were significantly higher in RA patients compared to control group after adjusting leptin level to BMI. RA patients had a significantly higher serum triglyceride and significantly lower serum HDL compared to control.

Leptin level was positivity correlated with BMI in both patients and controls. Triglyceride was significantly higher in overweight and obese control than in non-obese control.

Leptin concentration was significantly higher in Patients with high disease activity score (DAS more than 5.1) which included 31 patients than in Patients with low DAS (less than 5.1) which included 39 patients. Higher serum Leptin levels were associated with longer disease duration.

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Keywords

Rheumatoid arthritis and leptin, rheumatoid arthritis and prolactin.

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