(3.237.0.123)
Users online: 13991     
Ijournet
Email id
 

Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 7
First page : ( 829) Last page : ( 834)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.01679.6

Level of Type L Metacrylate Acid Copolymer as Microparticle Matrix Improves Lactobacillus casei Protection against Gastric Acid

Rahayu Ayun Dewi1, Setyawan Dwi1, Sugiyartono1,*

1Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Jl. Airlangga No.4-6, Airlangga, Gubeng, Surabaya, East Java, Indonesia

*Corresponding Author: Sugiyartono, Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Jl. Airlangga No.4-6, Airlangga, Gubeng, Surabaya, East Java, Indonesia, 60115

Online published on 19 August, 2019.

Abstract

Background

Lactobacillus casei is a probiotic that has an ability to protect the intestine, but is damaged due to the acid pH in the stomach. A system is needed to provide protection. Probiotic microencapsulation can provide protection against Lactobacillus casei by increasing the levels of methacrylic acid copolymers.

Objective

The aim of this study is to determine the effect of type L methacrylic acid copolymers as microparticle matrix on the protection system of Lactobacillus casei against acidic atmosphere.

Method

Lactobacillus casei probiotic microparticles were made from three formulas using matrix type L methacrylic acid copolymers with levels in formulas I, II, and III, each of which was 0.50%; 0.75%; and 1.00% by spray drying technique at 120°C inlet temperature.

Results

Moisture content decreased with the increasing levels of methacrylic acid copolymers from formulas I, II and III with 10.05% ± 0.49; 9.77% ± 0.19 and 7.45% ± 0.11 respectively. In determining particle size, the results increased simultaneously with the increasing levels of methacrylic acid copolymers in formulas I, II and III, which were 3.29 ± 0.07; 3.79 ± 0.06 and 4.34 ± 0.13 respectively.

Conclusion

Increasing the level of L type methacrylic acid copolymer as a matrix can increase the protection capability of Lactobacillus casei microparticles against gastric acid.

 

Top

Keywords

Probiotics, Lactobacillus casei, spray drying, capolymer.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
733,458,372 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.