Level of Type L Metacrylate Acid Copolymer as Microparticle Matrix Improves Lactobacillus casei Protection against Gastric Acid Rahayu Ayun Dewi1, Setyawan Dwi1, Sugiyartono1,* 1Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Jl. Airlangga No.4-6, Airlangga, Gubeng, Surabaya, East Java, Indonesia *Corresponding Author: Sugiyartono, Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Jl. Airlangga No.4-6, Airlangga, Gubeng, Surabaya, East Java, Indonesia, 60115
Online published on 19 August, 2019. Abstract Background Lactobacillus casei is a probiotic that has an ability to protect the intestine, but is damaged due to the acid pH in the stomach. A system is needed to provide protection. Probiotic microencapsulation can provide protection against Lactobacillus casei by increasing the levels of methacrylic acid copolymers. Objective The aim of this study is to determine the effect of type L methacrylic acid copolymers as microparticle matrix on the protection system of Lactobacillus casei against acidic atmosphere. Method Lactobacillus casei probiotic microparticles were made from three formulas using matrix type L methacrylic acid copolymers with levels in formulas I, II, and III, each of which was 0.50%; 0.75%; and 1.00% by spray drying technique at 120°C inlet temperature. Results Moisture content decreased with the increasing levels of methacrylic acid copolymers from formulas I, II and III with 10.05% ± 0.49; 9.77% ± 0.19 and 7.45% ± 0.11 respectively. In determining particle size, the results increased simultaneously with the increasing levels of methacrylic acid copolymers in formulas I, II and III, which were 3.29 ± 0.07; 3.79 ± 0.06 and 4.34 ± 0.13 respectively. Conclusion Increasing the level of L type methacrylic acid copolymer as a matrix can increase the protection capability of Lactobacillus casei microparticles against gastric acid. Top Keywords Probiotics, Lactobacillus casei, spray drying, capolymer. Top |