Evaluating the Biological Applications of Myristica fragrans Seeds for Bactericidal and Cytotoxic Effects Vibala B. V.1, Suganthi V.2, Praseetha P. K.3,* 1Research Scholar, Department of Nanotechnology, Noorul Islam Center for Higher Education, Kumarakovil, Kumaracoil, Thuckalay, Tamilnadu, India 2Assistant Professor, Department of Biotechnology, Sri Sankara Arts and Science College, Ernathur, Kanchipuram, Tamilnadu, India 3Professor, Head of the Department Department of Nanotechnology, Noorul Islam Center for Higher Education, Kumarakovil, Kumaracoil, Thuckalay, Tamilnadu, India *Corresponding Author: P. K. Praseetha, Professor, Head of the Department, Department of Nanotechnology, Noorul Islam Center for Higher Education, Kumarakovil, Kumaracoil-629180, Thuckalay, Tamilnadu, India, Email: crkpkp@gmail.com
Online published on 19 August, 2019. Abstract Introduction Bioactive compounds from herbal plants possess a wide range of pharmaceutical activities and one among them is Myristica fragrans (Nutmeg). Aim Antibacterial screening of the different solvent extracted phytoconstituents showed maximum growth inhibitory effect against E.coli and S. mutans. Agar well diffusion sensitivity testing method was adopted for this study. Method Acetone extract of the seeds also performed good bactericidal effect against the bacterial pathogens. Result MTT assay also demonstrated good cytotoxic effect against MCF-7 cell lines in a dose-dependent manner with inhibitory concentration (IC50) achieved at 62.5 μg/mL. Conclusion Based on the findings of the study, seeds of Myristica fragrans could be exploited in developing potential bioactive pharmaceutical drugs for effective treatment of cancer. Top Keywords Myristica fragrans Anti bacterial MTT assay Cytotoxicity. Top |