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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 7
First page : ( 1412) Last page : ( 1417)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.01788.1

Wound Healing Properties and Cytotoxicity of Gold Nanoparticles on MDCK Cell Lines (in Vitro Study)

Aljbory Najwa Kahtan1, Mohammed Nissren Jalal1, Ghaleb Rana A.3,*

1Dept. of Pharmacolgy, College of Medicine, University of Babylon, Babylon, Iraq

2Clinical Pharmacist, Ministry of Health, Babylon, Iraq

3Dept. of Anatomy and Histology, College of Medicine, University of Babylon, Babylon, Iraq

*Corresponding Author: Rana A. Ghaleb, Dept. of Anatomy and Histology, College of Medicine, University of Babylon, Babylon, Iraq, Email: Rana.a.ghaleb@uobabylon.edu.iq

Online published on 19 August, 2019.

Abstract

The research study was aimed to investigate the effect of Gold nanoparticles(AuNPs) at different concentration on the wound healing of Madin-Darby Canine Kidney epithelial normal cell line in comparison with control group. Gold nanoparticles were prepared in chemicals methods with diameter of 23-26nm. The cytotoxic effect of gold nanoparticles was tested on the (MDCK) cells. The AuNP concentrations of (500, 250, 125, 62.5, 32.25)μg/ml inhibit the proliferation of MDCK cells. The enhancement concentration was chosen for this research study. The wound was made on Madin-Darby Canine Kidney epithelial (MDCK) cell lines at diameter of 250 pixel. The wound size was measured at different time every 3hours starting from (12afternoon, 3h, 6h, 9h, 12midnight). The results observed there was a significant decrease (p≤0.001) in the size of wound at the concentration of Au NPs (15.6, 7.8)μg/ml respectively in comparison with control group.

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Keywords

MDCK cells, Wound, Healing, AuNPs, Cytotoxicity.

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