Prevalence and Determinants of Vitamin-D Status in Subjects with Type II Diabetes Mellitus Muley Arti1,*, Iyer Uma2 1Assistant Professor, Symbiosis School of Biological Sciences, Symbiosis International (Deemed) University, Symbiosis Knowledge Village Lavale, Pune, Maharashtra, India 2Professor, Department of Foods & Nutrition, Faculty of Family & Community Sciences, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara, Gujarat *Corresponding Author: Arti Muley, Assistant Professor, Symbiosis School of Biological Sciences, Symbiosis International (Deemed) University, Symbiosis Knowledge Village, Lavale, Pune, Maharashtra, India-412 115 Email- arti.muley@ssbs.edu.in
Online published on 19 August, 2019. Abstract Background Vitamin-D deficiency (VDD) is more evident in diabetic subjects as evidence shows its role in regulating some pathways related to diabetes development. It is hypothesized that vitamin-D influences glucose homeostasis by modulating inflammatory response. Hence the present study aimed to map the prevalence of VDD and identify associated determinants among type-II diabetic subjects. Methods One-hundred fourteen type-II diabetic subjects (30–65 years) who gave written consent were enrolled from a diabetic clinic for this cross sectional study. Background information was collected using a pre-tested semi-structured questionnaire. Anthropometric measurements were done by standard procedures. Serum 25(OH)D and other biochemical parameters were estimated in an NABL accredited laboratory using fasting blood samples. Data was analysed using SPSS version 20. Prevalence was reported as percentages. Pearson correlation was applied to find the association between determinants and multivariate analysis was performed to identify the predictor variables of vitamin-D status. Results were considered significant at p<0.05. Results About 89% of the subjects were vitamin-D deficient (serum 25(OH)D <20ng/ml). Significant higher values were observed for waist-stature-ratio and %body fat in the low vitamin-D group (<20ng/ml) when compared with the high vitamin-D group (≥20ng/ml). A significant negative correlation was observed between the vitamin-D levels and waist-circumference, waist-stature-ratio, BMI, %body fat, total cholesterol and LDL-C. Hypercholesterolemia (OR 7.5, 95% CI 0.9–60.3) and inflammation (OR 3.95; 95% CI 1.2–13.2) was significantly high among the low vitamin-D group. WSR, total T4, duration of diabetes, total proteins and LDL-C were identified as predictor variables of vitamin-D status through the regression model. Conclusion Vitamin-D deficiency was highly prevalent among the diabetic subjects. Anthropometric measurements and lipid values emerged as modifiable risk factors for poor vitamin-D status. This calls for positive behaviour change and lifestyle modification among the diabetic subjects. Top Keywords Vitamin-D deficiency, type-II diabetes mellitus, prevalence, risk factors, determinants. Top |