Prevalence and Antibiotic Resistance Profile of Coagulase Negative Staphylococci causing True Bacteraemia in a Tertiary care Hospital Singh Nipa1, Hota Srotaswini2, Panda Subhra Snigdha1,*, Pattnaik Dipti3, Praharaj Ashok3, Jena Jagadananda4 1Assistant Professor, Kalinga Institute of Medical Sciences, Bhubaneswar 26th Semester MBBS Student, Kalinga Institute of Medical Sciences, Bhubaneswar 3Professor, Kalinga Institute of Medical Sciences, Bhubaneswar 4Professor and HOD, Kalinga Institute of Medical Sciences, Bhubaneswar *Corresponding Author: Dr. Subhra Snigdha Panda Assistant Professor, Department of Microbiology, Kalinga Institute of Medical Sciences, P.O. KIIT, Bhubaneswar-751024, India
Online published on 13 November, 2019. Abstract Background As Coagulase negative Staphylococci (CoNS) are frequent contaminants of blood cultures, it is necessary to determine if CoNS in blood culture is due to clinically significant infection. This study aims to determine the prevalence of true bacteraemia due to CoNS in our institution as well as the antibiotic resistance profile of these CoNS isolates. Material and Method A prospective study was done for a period of 7 months. True or significant CoNS bacteraemia was determined by a modified clinical and microbiological criteria. Results CoNS were isolated from 144 (16.6%) of the total 866 blood cultures. CoNS species were considered true pathogens in 38 (26.4%) cases. The most common species isolated was Staphylococcus haemolyticus, 15 (39.5%) followed by Staphylococcus epidermidis, 7(18.4%). Highest sensitivity was to Vancomycin (100%) followed by Tigecycline (94.7%).Methicillin resistant CoNS (MR CoNS) was seen in 24(65%) among the 38 CoNS isolates causing true bacteraemia. There is an overall high prevalence of resistance to non beta lactam antibiotics among MR CoNS as compared to MS CoNS with the difference being statistically significant for ciprofloxacin (64.1% vs 18.1%, P < 0.001), erythromycin(76.4% vs 45.4%, P= 0.034) and rifampicin (48.7% vs 13.6%, P=0.039). Conclusion It is necessary to determine if CoNS bacteraemia is to be treated to prevent unnecessary expenditure and increasing antimicrobial resistance. Top Keywords Coagulase negative staphylococci, bacteraemia, contaminants, antimicrobial resistance. Top |