Role of Adropin in Women with Polycystic Ovary Syndrome Hamdi Rana Ali1,*, Abas Hanan Naama2, Alsaeed Fatin Abdul Aziz2 1Department of Biochemistry, Collage of Medicine, University of Baghdad 2Infertility Center, Baghdad Teaching Hospital *Corresponding Author: Rana Ali Hamdi, Department of Biochemistry, Collage of Medicine, University of Baghdad, Baghdad, Iraq Email: rana.chemist2006@yahoo.com
Online published on 13 November, 2019. Abstract Objective Evaluate serum adropin levels in women with polycystic ovary syndrome (PCOS) and compare their levels with BMI matched healthy controls. Also investigate the relation between serum adropin levels with insulin resistance and lipid profile. Materials and Method A case-control study included 78 women from 21 to 40 years of age. Women were divided into two groups: group (1) included 39 women with PCOS and group (2) included 39 healthy women (as controls). Each serum sample was analyzed for assessing adropin, fasting glucose, fasting insulin, HOMA-IR, and lipid profile. Results Mean serum adropin levels was significantly lower in women with PCOS as compared to healthy controls (P=0.001). Additionally, significant negative correlations were found between serum adropin levels and serum triglyceride (r=-0.418, P=0.04), total cholesterol (r=-0.842, P=0.0001) and HOMA-IR (r=-0.436, P=0.03) in patients group. Conclusion Low serum adropin may participate in the metabolic defects seen in polycystic ovary syndrome such as dyslipidemia and insulin resistance that in turn associated with other health problems such as hypertension, diabetes mellitus, and cardiovascular disease. Top Keywords Polycystic ovary syndrome, adropin, insulin resistance, lipid profile, insulin. Top |