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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 9
First page : ( 1291) Last page : ( 1296)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.02622.6

Role of Serum Activin A and Granulocyte Macrophage-colony Stimulating Factor in the Prediction of Pregnancy Outcome in PCOS and Non-PCOS Women Following ICSI

Al-Dujaily Saad S.1, Shukry Nagham T.2

1Biotechnology Research Center

2High Institute of Infertility Diagnosis and ART, Al-Nahrain University, Baghdad, Iraq

Online published on 13 November, 2019.

Abstract

Granulocyte macrophage-colony stimulating factor (GM-CSF) are a groups of glycoprotein growth factors, which are involved in the embryonic development and implantation process.

This study aimed to found out the role of serum activin A and G-CSF on the positive implantation leading to pregnancy outcome, in the PCOS and non-PCOS women following intra-cytoplasmic sperm injection.

In this study, eighty-eight women were enrolled and divided according to the cause of infertility, into 50 PCOS women, and 38 women diagnosed as non-PCOS, the selected women were undergoing ICSI. The activin A was measured in serum at the day of oocyte retrieval, and the GM-CSF was measured in the serum at the day of embryo transfer. All women participating in this study had the β-HCG test, 12–14 days after embryo transfer.

This study concluded that, serum activin A and GM-CSF levels are valuable in predicting pregnancy outcome in infertile PCOS women than non-PCOS women.

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Keywords

Serum activin A, Granulocyte macrophage, Colony stimulating factor, Prediction of pregnancy outcome, PCOS, non-PCOS women, ICSI.

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