Study the Effect of Cladosporium Spp. on Some Internal Organs of Experimental Animals Zghair Zainab R.* Zoonosis Unit, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq *Corresponding Author: Zainab R. Zghair, Zoonosis Unit, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq, Email: zzghair@yahoo.com
Online published on 13 November, 2019. Abstract This study was designed as Twenty four Balb C mice were used 6 weeks in age and both sexes weight from 25 grams were randomly divided into three groups each one contain 8 animals and suspension (2x106) cfu/intraperitoneal 0.3 cc were obtained first group as F1 group infected with cladosporium for two weeks, Second group as F2 group infected for three weeks and third group as control group injected with PBS 0.3 cc. Results of liver function were ALT, and Bilirubin F2 group had significantly increase (P<0.01) for tests ALT and bilirubin (83.55 ± 6.49), (5.75 ± 0.59) respectively when compared with control group; while F1 group had non-significantly increase (P<0.01). Histopathological showed lesions in group (F2) more severe than (F1)group specially in liver which appeared necrosis of hepatocytes and karyohexis of nucleus and granulomatous aggregation of inflammatory cells like macrophage and lymphocytes around bile ducts with aggregation of inflammatory cells as clusters between necrotic tissue, kidney revealed degeneration of some epithelial cells of renal tubules, lung showed infiltration of inflammatory cells like macrophage and vacculation the cytoplasm of alveolar endothelial cells, and showed necrosis and infiltration of inflammatory cells like macrophage in large numbers in spleen. Top Keywords Cladosporium spp, histopathology, and liver functions. Top |