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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 9
First page : ( 1399) Last page : ( 1404)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.02643.3

Oral Health condition among Kindergarten children in Relation to Salivary soluble Cluster of Differentiation 14 and Tool Like Receptor 2 (comparative study)

Khaudyer Aseel Taha1, Mohammed Ahlam Taha2, Al-Ghurabi Batool Hassan3

1Department of Pedodontic, College of Dentistry, University of Baghdad. Iraq

2Department of Pedodontic and Preventive Dentistry, College of Dentistry, University of Baghdad. Iraq

3Department of Basic Science, College of Dentistry, University of Baghdad. Iraq

Online published on 13 November, 2019.

Abstract

Oral health of preschool children can be deteriorating by dental caries and periodontal disease. Early childhood caries is highly prevalence dental public health problem that affect the primary tooth in children below the age of 71 months. Salivary soluble cluster of differentiation 14 and salivary toll like receptor 2 are proteins that have the ability to recognize different bacterial component and play role in prevention of infection. This study was conducted to determine the salivary levels of soluble cluster of differentiation 14 and soluble toll like receptor 2 in children with active dental caries and caries-free controls and found the correlation with gingival parameter. Sixty children with an age range between (4–5) years were participated in this study; they categorized into two groups, 30 children with severe stage of early childhood caries as the study group and 30 caries free children as the control group. Oral examination done by recording decay, missing, filled surfaces, measuring dental caries severity, gingival health status was assessed by using gingival index, in addition to plaque index. Saliva samples were collected from both groups. Enzyme-linked immunosorbent assay was carried out to estimate the salivary level of soluble cluster of differentiation 14 and soluble toll like receptor 2. The present study found significant elevation in the mean level of soluble cluster of differentiation among early childhood caries group, moreover there are no differences in mean level of soluble cluster of differentiation between caries severity groups. On the other hand, a positive nonsignificant correlation was found between the concentration of soluble cluster of differentiation in both groups and each of plaque index and gingival index. Regarding the soluble tool like receptor 2 a higher level in caries active group than caries free group was revealed without significant difference between them. Significant differences in soluble tool like receptor 2 mean levels was found between caries severity group. Furthermore, positive significant correlation was observed between salivary level of soluble tool like receptor 2 and gingival index in both groups, on the other hand, positive non-significant correlation was found between the levels of soluble tool like receptor 2 and plaque index. It can be conclude that the levels of salivary soluble cluster of differnatation 14 and tool like receptor 2 increased as the oral disease progress and they may have a suspected protective role against microbial burden. Salivary soluble cluster of differnatation 14 could be an important biomarker of caries activity.

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Keywords

CD14, TLR2, ECC.

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