Vitamin D levels in late Pre-Term neonates and its association with sepsis
*Correspondence: Dr. Kiran N Baliga Assistant Professor, Department Of Pediatrics, Kasturba Medical College, Manipal Academy Higher Education, Mangalore E-mail: email@example.com
Vitamin D deficiency is a major health concern & prevalence rates in preterm neonates is still not well defined. Role of Vitamin D deficiency in critically ill patients with sepsis has been reported in the adult population. This study aims at studying Vitamin D levels in late preterm neonates and its association with sepsis.
To estimate & identify Vitamin D deficiency in late Pre-termers, in turn studying their levels in late onset sepsis and estimating the change in Vitamin D levels with the onset of sepsis.
A total of 120 late pre-termers were included in the study. Gestation age calculated by New Ballard's score. Structured pro-forma recorded birth details. Baseline vitamin D levels of all babies were obtained on day 4). Those 67 neonates with features of late onset sepsis either clinically/haematological/culture were sub-grouped as cases & remaining 53 were controls. Subsequent vitamin D level was estimated in septic cases after 48 hours of onset
Mean value of vitamin D on day 4 was 18.9 indicating vitamin D deficiency (p<0.001). There was no difference in baseline vitamin D levels in those who developed sepsis and those who did not. Amongst cases, mean value of Vitamin D before onset of sepsis was 26.27ng/ml and 19.29ng/ml after 48 hours of onset; indicating a highly significant drop in vitamin D within 48 hours of onset of sepsis(p<0.001). There was no significant association between culture proven sepsis & vitamin D deficiency. Vitamin D deficiency does not predispose to sepsis.
There is need to establish normal Vitamin D levels in our population. There is no evidence in this study to say Vitamin D deficiency predisposes to sepsis. However there is significant drop in vitamin D levels with onset of sepsis.
Vitamin D, Late Preterm neonates, Late onset sepsis.