Histopathological alternations of placenta in pregnancy women complicated with gestational diabetes Mahmoud Estabraq A1,*, Qasim Ban J2, Al-Bakri Nahla A1 1Deprtment of Biology, College of Education for Pure Sciences (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq 2Department of Pathology, College of Medicine, Al-Nahrain University, Baghdad, Iraq *Corresponding author: Estabraq A Mahmoud E-mail: estabraq.a@ihcoedu.uobaghdad.edu.iq
Online published on 1 November, 2018. Abstract Diabetes mellitus is the metabolic disorder, which affect the pregnant mothers as well as their neonates because of its influence on the placenta, the occurrence of which is continue to increase. By studying the placentae of the gestational diabetic pregnancy and comparing it with the placentae of normal pregnancy, we can recognize the changes that occurs in placenta because of gestational diabetes, such as crowding of villi, increased villous number of immature intermediate villi, decreased terminal villi density, increased terminal villi size, numerous syncytial knots, basement membrane thickening in terminal villi, cytotrophoblast in terminal villi, decreased vascular-syncytial membrane thickness, extravillous fibrinoid, fibrosis, fibrinoid necrosis, stem villi and mature intermediate with indented margin, villi with continuous trophoblastic layer, immature intermediate villi with loose reticular stroma and basement membrane thickening as well as increased of Hofbauer cells population, calcification intracellular as well as extracellular, chorangiosis, thickening of villi vessels, fetal vessel thrombosis, nucleated fetal RBCs, edema in terminal and stem villi and villous edema in mature intermediate and which can affect the neonates. Top Keywords Placenta, Gestational diabetes, Histopathology. Top |