Association of apolipoprotein e polymorphism with cognitive functions in elderly Tadjudin N. Saelan1, Tanra Andi Jayalangkara2, Islam Andi Asadul3, As'ad Suryani4, Massi Muh. Nasrum5, Patellongi Ilhamjaya6, Prihantono Prihantono3 1Department of Psychiatry, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia 2Department of Psychiatry, Hasanuddin University, Makassar, Indonesia 3Department of Surgery, Hasanuddin University, Makassar, Indonesia 4Department of Nutrition, Hasanuddin University, Makassar, Indonesia 5Department of Microbiology, Hasanuddin University, Makassar, Indonesia 6Department of Physiology; Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Online published on 9 January, 2019. Abstract Objective This study aims to examine the association between apolipoprotein E polymorphism (APOE) and cognitive functions test using Montreal Cognitive Assesment-Indonesian version 2012 (MoCA-Ina) in elderly. Method A cross-sectional study of 112 elderly participants from two nursing homes in Jakarta. APOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results There are four genotypes: E2/E2 10(8.9%), E3/E3 38(33.9%), E3/E4 46(41.1%) and E4/E4 18(16.1%). The percentage of E2 allele 20(8.9%), E3 122(54.5%), E4 82(36.6%). The cognitive function test, MoCA-Ina ≥ 26: 34(40%) participants with genotype E2/E2 3(8.8%), E3/E3 7(20.6%), E3/E4 16(47.1%) and E4/E4 8(23.5%). MoCA-Ina < 26: 51(60%) 51 participants with genotype E2/E2 7(13.7%), E3/E3 14(27.5%), E3/E4 22(43.1%) and E4/E4 8(15.7%). A significant relationship between APOE gene polymorphism with MoCA-Ina-abstraction: E3/E4 vs. E3/E3 p 0.019, E4/E4 vs. E3/E3 p = 0.028, a significant relationship between APOE gene polymorphism with MoCA-Ina-language: E3/E4 vs. E2/E2 p = 0.03, E4/E4 vs. E2/E2 p 0.029, and a significant relationship between APOE gene polymorphism with naming: E3/E4 vs. E2/E2 p = 0.048. Conclusion High percentage of APOE allele E4 may be one of the causes of high cognitive function decline. APOE gene polymorphisms associated with the decreased cognitive function; abstraction, language, and naming. Allele E4 may be a potential factor for cognitive function decline. Top Keywords MoCA-Ina, Elderly, polymorphism, APOE, gene. Top |