Biological Activity of New Hydantoin Derivatives on Acinetobacter Baumannii Biofilm Formation Isolated from Clinical Sources Raheem Ihsan Ali1,*, Hussain Suzan Saadi1, Essa Rajwa Hasan2, Atia Abdul-Jabar Kh.3, Abdul Fatima Rammadan1 1Microbiology, College of Science 2Immunology and Microbiology, College of Science 3Department of Chemistry, College of Science, Mustansiryah University, Baghdad City, Iraq *Corresponding author: Ihsan Ali Raheem, Microbiology, College of Science, Mustansiryah University, Baghdad City, Iraq.
Online published on 2 February, 2019. Abstract Wholly 538 clinical samples of blood, burns, sputum, wounds and urine were involved in the current study which was done in 4 hospitals. The isolation and diagnosis of ffty-two Acinetobacter baumannii isolate 36.54% from blood specimens, whereas wounds specimens constituted 23.08%, burns specimens achieved 17.31%, sputum specimens formed 13.46% and a low percentage was in urine specimens which accomplished 9.62%. Totally isolates of bacteria were identifed via the biochemical, cultural and microbial characteristics and confrmed via VITEK 2 Compact system. It was found that all (100%) of bacteria isolates were resistant to amoxicillin-clavulanic acid and Cefepime, while Tobramycin was the most effective antibiotic. The isolates displayed the ability of biofilm creation via Microtitration plates method (M.T.P), from the whole number (52) isolates, (33) were producers, such as strong biofilm creators were (15) 45.46% and (18) 54.54% moderate though (19) 36.53% isolates were stately as weak or none biofilm producers. MIC for new hydantoin derivative (C12H13N3O2S) was determined against ffteen isolates were active in MIC values equal to 31.25μg/ml gave (7) A. baumannii isolates, while in MIC, values equal to 62.5μg/ml gave (5) isolates, and three isolates were active in MIC values equal to 125μg/ml. Top Keywords Acinetobacter baumannii, Hydantoin derivatives, Biofilm, Antibiotics. Top |