DNA-In Situ Localization of Human Herpes Virus-8 and Mutated P57 Genes Sequences in Tissues from a Group of Female Iraqi Patients with Breast Tumors Nasser Israa Habeeb1, Al-Alwany Shakir H. Mohammed1,* 1College of Science, Babylon University, Hillah City, Iraq *Corresponding author: Shakir H. Mohammed Al-Alwany, College of Science, Babylon University, Hillah City, Iraq; E-mail: shakir_immuno@yahoo.com
Online published on 2 February, 2019. Abstract This study was designed as a retrospective case-control study research. A total number of (100) formalinfxed, paraffn embedded Breast tissues was included. These tissues were including 40 malignant breast tumors, 40 benign breast tumors and 20 of apparently healthy breast sections which were included as baseline control. The mean age of the patients with breast carcinoma was higher (46.80 ± 12.517 years) than the mean age of the benign tumor (34.70 ± 14.4 years), followed by mean age of those females in the group of apparently healthy control (34.70 ± 14.4 years). The positive results of HHV-8-CISH detection in malignant breast tumors, where 32.5% (13 out of 40 tissues) showed positive signals. While, in the benign breast tumors group were 15% (6 out of 40 tissues). Regarding malignant breast tumors group, the total percentage of positive mutated P57-CISH detection was in 55%(22 out of 40) breast cancer cases and in 35%(14 out of 40) benign breast tumor group, while none of positive mutated P57-CISH detection in control breast tissues group. Top Keywords HHV-8, Mutated p57, CISH, Breast tumors. Top |