The Efectiveness of 0.03% Bimatoprost Solution Vs Minoxidil 5% in Androgenic Alopecia Tabri Farida1,*, Anwar Anis Irawan1, Adriani Anni1, Aryaningrum Dwi1 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Hasanuddin, Makassar *Corresponding Author: Farida Tabri Department of Dermatology and Venerology Faculty of Medicine Universitas Hasanuddin, Makassar 90245, Indonesia, Email: farida.tabri.dv@gmail.com
Online published on 2 February, 2019. Abstract Introduction. Androgenic alopecia (AGA) is the most common type of progressive hair loss with an incidence that increases with age. The role of dihydrotestosterone in AGA pathogenesis has been wellestablished. However, an incidental eyelash and eyebrow growth in patients treated with prostaglandin analogues, bimatoprost and latanoprost, has led to a hypothesis of their possible roles in inducing scalp hair growth. Methods This randomized-controlled trial included 6 male subjects, randomized into 2 groups, each consisting of 8 subjects which were given either topical bimatoprost 0.03% or topical minoxidil 5%. Hairs on the affected areas were shaved and both the terminal hair (hairs with diameter of >1 mm) diameter and terminal hair count were measured using a dermoscope on week 0, 4, 8, and 12. A hair sample from the target area was taken and the prostaglandin D2 level was examined before and after 12 weeks of therapy by using ELISA. Independent T-test and paired T-test were used to compare the result. Results When both groups were compared, no signifcant difference in terminal hair count and diameter was observed (p> 0.05). Both the bimatoprost and minoxidil group showed a mean increase of terminal hair diameter and hair count after 12 weeks (p<0.05). There was a decrease PGD2 concentration in bimatoprost 0.03% group, but an increase in the minoxidil 5% group (P>0.05). No signifcant side effects were observed. Conclusion; A 12-week topical application of bimatoprost 0.03% results in a signifcant increase in terminal hair diameter and count. Further studies with longer follow-up duration are needed to establish the effectiveness of bimatoprost in AGA treatment. Top Keywords Bimatoprost 0.03%, minoxidil 5%, androgenic alopecia, prostaglandin. Top |