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Indian Journal of Public Health Research & Development
Year : 2018, Volume : 9, Issue : 12
First page : ( 2512) Last page : ( 2515)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2018.02147.2

Describing Role of Bacteria in Carcinogenesis with Special Emphasis on Fusobacterium species in Oral Cancer: An Overview

Mandal Devi Prasad1, Rath Shakti2, Panda Swagatika3, Mohanty Neeta4,*

1PhD Scholar,Central Research Laboratory Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India

2Assistant Professor (Research), Central Research Laboratory Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India

3Associate Professor, Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India

4Professor & Head, Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India

*Corresponding Author: Dr. Neeta Mohanty Professor & Head, Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha ‘O ’Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India Email: dr.neetamohanty@gmail.com

Online published on 2 February, 2019.

Abstract

Oral squamous cell carcinoma (OSCC) is one of the major global health problems with high prevalence and morbidity rates. This continues to be a major health concern, even after several decades of research and advancement in medical science. Studies conducted in last decade has established the fact that bacteria can be one of the etiologic agents of cancer. One such bacterium, Fusobacterium nucleatum has been identified as a potential carcinogenic organism. The methodologies ranging from traditional culture techniques to 16S rRNA metagenomics has established a significant difference in microbial counts between cancerous and healthy tissues. This article provides an overview on the association between bacteria and oral carcinogenesis with a special reference to Fusobacterium infection.

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Keywords

Oral squamous cell carcinoma, Bacteria, Fusobacterium nucleatum, etiologic agents.

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