Describing Role of Bacteria in Carcinogenesis with Special Emphasis on Fusobacterium species in Oral Cancer: An Overview Mandal Devi Prasad1, Rath Shakti2, Panda Swagatika3, Mohanty Neeta4,* 1PhD Scholar,Central Research Laboratory Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India 2Assistant Professor (Research), Central Research Laboratory Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India 3Associate Professor, Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India 4Professor & Head, Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University). Bhubaneswar. Odisha. India *Corresponding Author: Dr. Neeta Mohanty Professor & Head, Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha ‘O ’Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India Email: dr.neetamohanty@gmail.com
Online published on 2 February, 2019. Abstract Oral squamous cell carcinoma (OSCC) is one of the major global health problems with high prevalence and morbidity rates. This continues to be a major health concern, even after several decades of research and advancement in medical science. Studies conducted in last decade has established the fact that bacteria can be one of the etiologic agents of cancer. One such bacterium, Fusobacterium nucleatum has been identified as a potential carcinogenic organism. The methodologies ranging from traditional culture techniques to 16S rRNA metagenomics has established a significant difference in microbial counts between cancerous and healthy tissues. This article provides an overview on the association between bacteria and oral carcinogenesis with a special reference to Fusobacterium infection. Top Keywords Oral squamous cell carcinoma, Bacteria, Fusobacterium nucleatum, etiologic agents. Top |